Description

(trans-Racemic) 1-tert-Butyl 3-Methyl 4-(5,6-Di-Methoxypyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex pyrrolidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing diverse chemical libraries based on the pyrrolidine core.
• Process Chemistry Development: Serves as a critical starting material or intermediate for developing scalable, cost-effective synthetic routes under GMP conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and novel organic synthesis methodologies.
• Pre-clinical Development: Integral component in the preparation of compounds for pharmacological profiling and toxicology studies.

Basic Information

Product Name	(trans-Racemic) 1-tert-Butyl 3-Methyl 4-(5,6-Di-Methoxypyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate
CAS No.	1217698-80-0
Molecular Formula	C22H32N2O6
Molecular Weight	420.50 g/mol
Synonyms	1-tert-Butyl 3-methyl 4-(5,6-dimethoxypyridin-3-yl)pyrrolidine-1,3-dicarboxylate; 4-(5,6-Dimethoxy-3-pyridinyl)-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; trans-1-Boc-3-methyl 4-(5,6-dimethoxypyridin-3-yl)pyrrolidine-1,3-dicarboxylate; (±)-1-tert-Butyl 3-methyl 4-(5,6-dimethoxypyridin-3-yl)pyrrolidine-1,3-dicarboxylate; 1217698-80-0; Pyrrolidine-1,3-dicarboxylic acid, 4-(5,6-dimethoxy-3-pyridinyl)-, 1-(1,1-dimethylethyl) 3-methyl ester; 1-Boc-3-methyl 4-(5,6-dimethoxypyridin-3-yl)pyrrolidine-1,3-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of (trans-Racemic) 1-tert-Butyl 3-Methyl 4-(5,6-Di-Methoxypyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and opened under inert atmosphere when handling is required for extended periods to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.