Description

(Rac-Trans)-1-tert-Butyl 3-Methyl 4-(5,6-Dimethoxypyridin-2-Yl)Pyrrolidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrrolidine scaffold. This compound matters for its critical role as a key building block in the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in neurological and oncological research. Pharmaceutical R&D teams and fine chemical manufacturers need this material to develop new therapeutic candidates, where its defined stereochemistry and high purity are essential for ensuring reproducible synthetic outcomes and final product quality.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of target APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: The rac-trans mixture provides a starting point for chiral resolution or asymmetric synthesis of enantiomerically pure derivatives.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical development from discovery to clinical trials.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API production.

Basic Information

Item	Detail
Product Name	(Rac-Trans)-1-tert-Butyl 3-Methyl 4-(5,6-Dimethoxypyridin-2-Yl)Pyrrolidine-1,3-Dicarboxylate
CAS No.	1217674-57-1
Molecular Formula	C22H32N2O6
Molecular Weight	420.50 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-(methoxycarbonyl)-4-(5,6-dimethoxypyridin-2-yl)pyrrolidine; tert-Butyl 3-methyl 4-(5,6-dimethoxypyridin-2-yl)pyrrolidine-1,3-dicarboxylate; 4-(5,6-Dimethoxy-2-pyridinyl)-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; (rac-trans)-1-Boc-3-methyl 4-(5,6-dimethoxypyridin-2-yl)pyrrolidine-1,3-dicarboxylate; Pyrrolidine-1,3-dicarboxylic acid, 4-(5,6-dimethoxy-2-pyridinyl)-, 1-(1,1-dimethylethyl) 3-methyl ester, (3R,4S)-rel-; BOC-Pyrrolidine Intermediate 1217674-57-1
EINECS	Contact for details

Quality Control

Our (Rac-Trans)-1-tert-Butyl 3-Methyl 4-(5,6-Dimethoxypyridin-2-Yl)Pyrrolidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.