Description

Mefloquine CAS NO 1217653-15-0 is a synthetic quinoline-methanol derivative with potent antimalarial activity. This compound is critical for the prophylaxis and treatment of chloroquine-resistant strains of *Plasmodium falciparum* malaria. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers, research institutions, and global health organizations involved in tropical medicine and infectious disease control.

Application

• Pharmaceutical API: Primary use as the active ingredient in antimalarial tablet formulations for both treatment and prevention.
• Clinical Research: Used in studies investigating drug resistance, pharmacokinetics, and new combination therapies for malaria.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Military & Travel Medicine: Formulated for prophylactic use by travelers and military personnel deploying to malaria-endemic regions.
• Veterinary Medicine: Potential application in veterinary protocols for parasitic infections, subject to regional regulatory approvals.
• Drug Synthesis Intermediate: Acts as a key chemical intermediate in the synthesis of related quinoline-based therapeutic agents.

Basic Information

Product Name	Mefloquine
CAS No.	1217653-15-0
Molecular Formula	C17H16F6N2O
Molecular Weight	378.31 g/mol
Synonyms	Mefloquine Hydrochloride; Lariam; Mephaquine; WR 142,490; (R*,S*)-(±)-erythro-α-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; (±)-erythro-Mefloquine; 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, (αR)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Mefloquine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with typical specifications aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.