Description

S-4-n-Boc-2-Cyanopiperidine is a high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined intermediate that streamlines the production of complex pharmaceutical molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system.
• API Development: Used in research and process chemistry for constructing the core piperidine scaffolds found in numerous bioactive molecules.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce chiral centers with high enantiomeric purity.
• Medicinal Chemistry Research: A versatile building block for creating focused libraries of compounds for structure-activity relationship (SAR) studies.
• Peptidomimetics: Integration into peptide-like structures to enhance metabolic stability and bioavailability.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production runs.

Basic Information

Product Name	S-4-n-Boc-2-Cyanopiperidine
CAS No.	1217650-60-6
Molecular Formula	C12H20N2O2
Molecular Weight	224.30 g/mol
Synonyms	(S)-1-tert-Butyl 4-cyano-2-piperidinecarboxylate; (S)-1-Boc-4-cyano-2-piperidinecarboxylic acid; (S)-N-Boc-4-cyano-2-piperidinecarboxylic acid; (S)-4-Cyano-1-Boc-piperidine-2-carboxylic acid; (S)-1-(tert-Butoxycarbonyl)-4-cyano-2-piperidinecarboxylic acid; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-cyanopiperidine-2-carboxylic acid; S-4-Cyano-1-Boc-piperidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our S-4-n-Boc-2-Cyanopiperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, chiral excess, and impurity profiles to ensure compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.