Description

R-1-Cbz-3-(Boc-Aminomethyl)-Pyrrolidine is a high-purity, bifunctional protected pyrrolidine derivative designed for advanced pharmaceutical synthesis. This compound serves as a critical chiral building block and versatile intermediate in the construction of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid, nitrogen-containing pyrrolidine scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• PROTAC & Molecular Glue Development: Serves as a linker or core component in the design of targeted protein degradation therapeutics.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring specific, protected heterocyclic intermediates.

Basic Information

Product Name	R-1-Cbz-3-(Boc-Aminomethyl)-Pyrrolidine
CAS No.	1217622-63-3
Molecular Formula	C19H28N2O4
Molecular Weight	348.44 g/mol
Synonyms	(R)-1-((Benzyloxy)carbonyl)-3-((tert-butoxycarbonyl)aminomethyl)pyrrolidine; (R)-1-Cbz-3-(Boc-aminomethyl)pyrrolidine; (R)-1-Carbobenzyloxy-3-(N-Boc-aminomethyl)pyrrolidine; (R)-N-Boc-1-Cbz-3-aminomethylpyrrolidine; (R)-1-(Benzyloxycarbonyl)-3-((tert-butoxycarbonylamino)methyl)pyrrolidine; (3R)-1-[(Benzyloxy)carbonyl]-3-[[(tert-butoxycarbonyl)amino]methyl]pyrrolidine; Pyrrolidine, 1-[(phenylmethoxy)carbonyl]-3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, (3R)-
EINECS	Contact for details

Quality Control

Our R-1-Cbz-3-(Boc-Aminomethyl)-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.