Description

(2R)-7-Hydroxy-3'-Methylspiro[Chromene-2,1'-Cyclohexan]-4(3H)-One is a high-purity, chiral spirocyclic compound of significant interest in advanced organic synthesis. Its unique molecular architecture makes it a valuable key intermediate or building block for the development of complex, biologically active molecules. This product is primarily targeted at pharmaceutical research and development organizations and fine chemical manufacturers requiring precise stereochemistry for their synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting the central nervous system or metabolic diseases.
• Asymmetric Synthesis Building Block: Utilized in the construction of complex, stereochemically defined molecular frameworks due to its rigid spirocyclic core.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Reference Standard: Used as an analytical standard for method development, quality control, and regulatory submissions in pharmaceutical manufacturing.
• Fine Chemical Synthesis: Acts as a specialized starting material for the production of high-value agrochemicals or functional materials.

Basic Information

Product Name	(2R)-7-Hydroxy-3'-Methylspiro[Chromene-2,1'-Cyclohexan]-4(3H)-One
CAS No.	1217538-35-6
Molecular Formula	C16H18O3
Molecular Weight	258.31 g/mol
Synonyms	(2R)-7-Hydroxy-3'-methylspiro[chromene-2,1'-cyclohexan]-4(3H)-one; (R)-7-Hydroxy-3'-methylspiro[chromene-2,1'-cyclohexane]-4(3H)-one; 7-Hydroxy-3'-methylspiro[chromene-2,1'-cyclohexan]-4(3H)-one, (2R)-; Spiro[chromene-2,1'-cyclohexan]-4(3H)-one, 7-hydroxy-3'-methyl-, (2R)-; 1217538-35-6; (2R)-7-Hydroxy-3'-methyl-1-oxaspiro[4.5]dec-3-en-4-one (alternative fused ring representation).
EINECS	Contact for details

Quality Control

Our (2R)-7-Hydroxy-3'-Methylspiro[Chromene-2,1'-Cyclohexan]-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, handling should be performed under subdued light or using amber glass containers to prevent degradation. For long-term storage, consider an inert atmosphere to mitigate potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.