Description

(4S)-(3,4-Dichlorophenyl)-3,4-Dihydro-1,2-Epoxy-1-o-Triethylsilyl-1-Naphthol is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined epoxy-naphthol structure. This compound matters for its critical role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry is essential for biological activity. Pharmaceutical R&D and process chemistry teams need it for developing and scaling up novel therapeutic agents, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex, biologically active molecules and novel APIs.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct molecules with defined three-dimensional configurations.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Development: Used in the scale-up and optimization of synthetic routes for candidate drugs in preclinical and clinical development.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying enzyme mechanisms or biological pathways.

Basic Information

Product Name	(4S)-(3,4-Dichlorophenyl)-3,4-Dihydro-1,2-Epoxy-1-o-Triethylsilyl-1-Naphthol
CAS No.	1217528-57-8
Molecular Formula	C28H28Cl2O2Si
Molecular Weight	495.51 g/mol
Synonyms	(4S)-1-[(Triethylsilyl)oxy]-1,2-epoxy-3-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-4-ol; (4S)-3-(3,4-Dichlorophenyl)-1,2-epoxy-1-[(triethylsilyl)oxy]-1,2,3,4-tetrahydronaphthalen-4-ol; 1,2-Epoxy-1-[(triethylsilyl)oxy]-3-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-4-ol, (4S)-; Silyl-protected epoxy-naphthol intermediate; CAS 1217528-57-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of (4S)-(3,4-Dichlorophenyl)-3,4-Dihydro-1,2-Epoxy-1-o-Triethylsilyl-1-Naphthol is analyzed using advanced techniques like HPLC, GC, and NMR to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP principles for pharmaceutical intermediates to ensure reliable supply and batch-to-batch consistency for critical R&D and scale-up work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.