Description

5-Chloro-2-Isopropoxypyridin-3-Ylboronic Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules via cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients, where precise molecular architecture is critical.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, requiring specific heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, enabling the efficient construction of biaryl and heterobiaryl systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Chloro-2-Isopropoxypyridin-3-Ylboronic Acid
CAS No.	1217501-41-1
Molecular Formula	C8H11BClNO3
Molecular Weight	215.44 g/mol
Synonyms	(5-Chloro-2-isopropoxypyridin-3-yl)boronic acid; 3-Borono-5-chloro-2-isopropoxypyridine; 5-Chloro-2-isopropoxy-3-pyridineboronic acid; 5-Chloro-2-(1-methylethoxy)-3-pyridineboronic acid; 2-Isopropoxy-5-chloropyridine-3-boronic acid; 1217501-41-1; 5-Chloro-2-isopropoxy-3-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Isopropoxypyridin-3-Ylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR (¹H, ¹³C, ¹¹B), and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this material should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and potential decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.