Description

3-Chloro-2-Fluoropyridine-4-Boronic Acid is a high-value, multi-functional heterocyclic boronic acid building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a building block for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and OFETs, due to the pyridine core's electron-accepting properties.
• Chemical Biology & Proteomics: Utilized in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Custom Synthesis & Contract Research: A vital reagent for custom synthesis organizations (CSOs) and CROs serving the global life sciences market.

Basic Information

Item	Details
Product Name	3-Chloro-2-Fluoropyridine-4-Boronic Acid
CAS No.	1217500-55-4
Molecular Formula	C5H4BClFNO2
Molecular Weight	174.35 g/mol
Synonyms	(3-Chloro-2-fluoropyridin-4-yl)boronic acid; 3-Chloro-2-fluoro-4-pyridineboronic acid; 4-Borono-3-chloro-2-fluoropyridine; 2-Fluoro-3-chloropyridine-4-boronic acid; 3-Chloro-2-fluoro-4-pyridinylboronic acid; 1217500-55-4; 3-Chloro-2-fluoropyridine-4-boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoropyridine-4-Boronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports compliance with ISO standards and the needs of cGMP environments for preclinical and early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under an inert atmosphere (argon/nitrogen) and stored in a desiccator for long-term stability. Recommended storage temperature is 2-8°C for prolonged shelf life.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.