Description

n-Boc-6-Azido-L-Norleucine (Dicyclohexylammonium) Salt is a high-purity, protected amino acid derivative designed for advanced chemical synthesis. This compound is a critical building block for the development of novel peptide-based therapeutics and bioconjugates, offering a reactive azido handle for bioorthogonal click chemistry. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly those focused on targeted drug delivery systems, antibody-drug conjugates (ADCs), and peptide library generation.

Application

• Peptide Synthesis: Serves as a key intermediate for the solid-phase and solution-phase synthesis of modified peptides, incorporating non-natural amino acids with clickable functionalities.
• Antibody-Drug Conjugate (ADC) Development: Used to synthesize linker-payload constructs, enabling the site-specific conjugation of cytotoxic agents to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Chemical Biology Probes: Enables the labeling and study of biomolecules in live cells through bioorthogonal reactions, facilitating target identification and validation.
• Material Science & Polymer Chemistry: Acts as a functional monomer for creating smart polymers and hydrogels with tailored biological properties for drug delivery and tissue engineering.
• Proteomics Research: Utilized in activity-based protein profiling (ABPP) to tag and identify enzyme active sites within complex proteomes.
• Glycopeptide & Glycoprotein Mimetics: Facilitates the synthesis of glycoconjugates and mimetics for studying carbohydrate-protein interactions and vaccine development.

Basic Information

Product Name	n-Boc-6-Azido-L-Norleucine (Dicyclohexylammonium) Salt
CAS No.	1217451-48-3
Molecular Formula	C23H45N5O4
Molecular Weight	455.64 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-6-azidohexanoic acid dicyclohexylammonium salt; Nα-Boc-6-azido-L-norleucine DCHA salt; Boc-Azn-OH·DCHA; tert-Butyl (S)-(6-azido-1-oxo-1-(dicyclohexylamino)hexan-2-yl)carbamate; 6-Azido-L-norleucine, N-Boc-, dicyclohexylammonium salt; Boc-L-6-Azidonorleucine Dicyclohexylamine Salt; (S)-2-((tert-Butoxycarbonyl)amino)-6-azidohexanoic acid dicyclohexylammonium salt
EINECS	Contact for details

Quality Control

Our n-Boc-6-Azido-L-Norleucine (Dicyclohexylammonium) Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.