Description

2-(n-Boc-Aminomethyl)-5-(Trifluoromethyl)Pyridine is a high-purity, protected amine building block essential for modern pharmaceutical and agrochemical research and development. This compound is a critical intermediate in the synthesis of complex molecules, particularly in constructing active pharmaceutical ingredients (APIs) and advanced crop protection agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel drug candidates and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel small-molecule drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require the pyridine and trifluoromethyl motifs.
• Peptidomimetics & PROTACs: Serves as a versatile component in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its protected aminomethyl handle.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	2-(n-Boc-Aminomethyl)-5-(Trifluoromethyl)Pyridine
CAS No.	1216276-20-8
Molecular Formula	C13H17F3N2O2
Molecular Weight	290.28 g/mol
Synonyms	2-((tert-Butoxycarbonylamino)methyl)-5-(trifluoromethyl)pyridine; 2-[(Boc-amino)methyl]-5-(trifluoromethyl)pyridine; 2-(Boc-aminomethyl)-5-trifluoromethylpyridine; tert-Butyl N-[[5-(trifluoromethyl)pyridin-2-yl]methyl]carbamate; Boc-AMTFP; 2-(N-Boc-aminomethyl)-5-(trifluoromethyl)pyridine; 5-Trifluoromethyl-2-pyridinemethanamine, N-BOC-
EINECS	Contact for details

Quality Control

Our 2-(n-Boc-Aminomethyl)-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our customers' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.