Description

12-Azidododecylmethanethiosulfonate is a specialized bifunctional chemical reagent featuring both an azide and a methanethiosulfonate group. This compound matters for its unique ability to facilitate site-specific bioconjugation and surface functionalization via orthogonal click chemistry and thiol-disulfide exchange reactions. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, materials science, and proteomics for labeling proteins, modifying nanoparticles, and creating functionalized surfaces.

Application

• Protein Labeling and Modification: Site-specific conjugation of fluorophores, drugs, or other probes to cysteine residues in proteins.
• Surface Functionalization: Creating reactive azide-terminated monolayers on gold or other surfaces for subsequent click chemistry modifications.
• Polymer and Biomaterial Synthesis: As a crosslinker or functional monomer to introduce azide groups into polymers for hydrogel formation or smart material design.
• Lipid and Membrane Research: Incorporation into lipid bilayers to study membrane dynamics or create targeted liposomal delivery systems.
• Antibody-Drug Conjugate (ADC) Development: A key intermediate for constructing stable, homogeneous linker-payload systems.
• Nanoparticle Functionalization: Coating nanoparticles to provide a bio-orthogonal handle for attaching targeting ligands or imaging agents.
• Activity-Based Protein Profiling (ABPP): Development of chemical probes to monitor enzyme activity in complex biological samples.
• Diagnostic Assay Development: Creating stable, high-affinity capture surfaces for biosensors and diagnostic platforms.

Basic Information

Product Name	12-Azidododecylmethanethiosulfonate
CAS No.	1215670-42-0
Molecular Formula	C₁₃H₂₇N₃O₂S₂
Molecular Weight	321.50 g/mol
Synonyms	MTS-azide C12; 12-Azidododecyl methanethiosulfonate; Azido-PEG12-MTS; S-(12-Azidododecyl) methanethiosulfonate; 1-Azido-12-(methanesulfonylthio)dodecane; Azidoalkyl MTS reagent; N3-C12-MTS; Azido-terminated methanethiosulfonate linker
EINECS	Contact for details

Quality Control

Our 12-Azidododecylmethanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and reliability for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.