Description

n-Succinimidoxycarbonyl-β-Alanine n-Succinimidyl Ester 1,4- Dioxane Complex is a specialized heterobifunctional crosslinking reagent designed for bioconjugation. This compound is critical for creating stable amide bonds between biomolecules, offering a reactive succinimidyl ester group for efficient coupling to primary amines. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and life science sectors for developing antibody-drug conjugates (ADCs), protein labeling, and advanced biomaterial synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: A key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific labeling of proteins, enzymes, and peptides with fluorophores, biotin, or other functional probes.
• Biomaterial and Hydrogel Fabrication: Crosslinking agent for modifying polymers and creating functionalized surfaces or 3D matrices for cell culture and tissue engineering.
• Diagnostic Reagent Development: Used in the preparation of enzyme conjugates and labeled antigens/antibodies for immunoassays (ELISA, lateral flow tests).
• Immobilization Chemistry: Facilitates the covalent attachment of biomolecules to solid supports such as beads, chips, and sensor surfaces.
• Small Molecule-Protein Conjugation: Enables the study of drug-protein interactions and the development of targeted therapeutic agents.

Basic Information

Product Name	n-Succinimidoxycarbonyl-β-Alanine n-Succinimidyl Ester 1,4- Dioxane Complex
CAS No.	1215667-16-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	β-Alanine, N-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-, 2,5-dioxo-1-pyrrolidinyl ester, 1,4-dioxane complex; NSC 1,4-Dioxane Complex; Succinimidyl 3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropanoate 1,4-Dioxane Adduct; B-Alanine NHS Ester Dioxane Complex; Heterobifunctional Crosslinker NHS Ester; N-Succinimidyl 3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropanoate 1,4-Dioxane Solvate
EINECS	Contact for details

Quality Control

Our n-Succinimidoxycarbonyl-β-Alanine n-Succinimidyl Ester 1,4- Dioxane Complex is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvent content, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
1,4-Dioxane Content	As per complex stoichiometry

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.