Description

Difluoro[3-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoroacetic acid and trifluoromethylpyridine moieties, makes it indispensable for introducing fluorine atoms and modulating the physicochemical properties of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized fluorinated ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Advanced Material Research: A building block for fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	Difluoro[3-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid
CAS No.	1215579-44-4
Molecular Formula	C8H4F5NO2
Molecular Weight	241.12 g/mol
Synonyms	2-(Difluoroacetic acid)-3-(trifluoromethyl)pyridine; [3-(Trifluoromethyl)pyridin-2-yl]difluoroacetic acid; 2-(3-Trifluoromethyl-2-pyridyl)-2,2-difluoroacetic acid; 2,2-Difluoro-2-[3-(trifluoromethyl)pyridin-2-yl]acetic acid; α,α-Difluoro-3-(trifluoromethyl)picolinic acid; DFTPA; Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our Difluoro[3-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades (e.g., >97%, >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.