Description

Ethyl 2-(3-Chloro-2-Fluorophenyl)-2,2-Difluoroacetate is a high-value, multi-fluorinated aromatic ester building block designed for advanced chemical synthesis. This compound matters because its unique structure, featuring both aryl and gem-difluoroacetate moieties, enables the precise introduction of fluorine atoms to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where fluorine incorporation enhances efficacy and environmental profile.
• Fluorinated Building Block: Serves as a versatile precursor in organic synthesis for constructing complex molecules with tailored properties via reactions at the ester or aromatic groups.
• Material Science Research: Employed in the development of specialty polymers and advanced materials where fluorinated aromatic units can impart unique thermal stability, chemical resistance, or optical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms.

Basic Information

Product Name	Ethyl 2-(3-Chloro-2-Fluorophenyl)-2,2-Difluoroacetate
CAS No.	1215205-78-9
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	Ethyl 3-Chloro-2-fluorobenzoyldifluoroacetate; 2-(3-Chloro-2-fluorophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl α,α-Difluoro-3-chloro-2-fluorophenylacetate; Acetic acid, 2-(3-chloro-2-fluorophenyl)-2,2-difluoro-, ethyl ester; Ethyl 2,2-Difluoro-2-(3-chloro-2-fluorophenyl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Chloro-2-Fluorophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your compliance needs in regulated development and production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.