Description

Diethyl(5-Bromopyridin-2-Yl)Malonate is a high-purity brominated pyridine derivative and a versatile malonate ester building block. This compound is essential for facilitating complex organic syntheses, particularly in the construction of heterocyclic scaffolds and active pharmaceutical ingredients (APIs). It is primarily sought by research chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for its role in cross-coupling reactions and functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing functionalized pyridine cores for kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require brominated heterocyclic structures.
• Material Science Research: Serves as a building block for creating organic ligands, metal-organic frameworks (MOFs), and functional polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes, tags, and linkers for studying biological systems.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory synthesis in university and CRO laboratory settings.

Basic Information

Product Name	Diethyl(5-Bromopyridin-2-Yl)Malonate
CAS No.	1215098-80-8
Molecular Formula	C₁₂H₁₄BrNO₄
Molecular Weight	316.15 g/mol
Synonyms	Diethyl (5-bromopyridin-2-yl)malonate; 2-(5-Bromo-2-pyridinyl)propanedioic acid diethyl ester; 5-Bromo-2-pyridylmalonic acid diethyl ester; Diethyl 5-bromopyridine-2-ylmalonate; (5-Bromopyridin-2-yl)malonic acid diethyl ester; Propanedioic acid, 2-(5-bromo-2-pyridinyl)-, diethyl ester; Diethyl (5-bromo-2-pyridyl)malonate
EINECS	Contact for details

Quality Control

Our Diethyl(5-Bromopyridin-2-Yl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.