Description

5-Bromo-2-(4-(trifluoromethyl)phenyl)pyridine is a high-value brominated and fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a bromine substituent and a trifluoromethylphenyl group, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the synthesis of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form biaryl structures.
• Ligand Preparation: Useful for the synthesis of novel nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	5-Bromo-2-(4-(trifluoromethyl)phenyl)pyridine
CAS No.	1215074-30-8
Molecular Formula	C12H7BrF3N
Molecular Weight	302.09 g/mol
Synonyms	5-Bromo-2-[4-(trifluoromethyl)phenyl]pyridine; 2-(4-Trifluoromethylphenyl)-5-bromopyridine; 5-Bromo-2-(4-trifluoromethylphenyl)pyridine; 5-Bromo-2-(α,α,α-trifluoro-p-tolyl)pyridine; 1215074-30-8; 5-Br-2-(4-CF3-Ph)Py
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(4-(trifluoromethyl)phenyl)pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.