Description

tert-Butyl 6-Iodo-2,3-Dihydro-1H-Pyrido-[2,3-B][1,4]Oxazine-1-Carboxylate is a high-value, heterocyclic building block featuring a fused pyrido-oxazine core with a reactive iodine substituent. This compound matters as a critical intermediate in modern pharmaceutical research, enabling the synthesis of complex molecules through versatile cross-coupling and functionalization chemistry. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Suzuki-Miyaura Cross-Coupling: The iodine atom serves as an excellent handle for palladium-catalyzed coupling with various boronic acids to introduce diverse aryl and heteroaryl groups.
• Buchwald-Hartwig Amination: Used in palladium-catalyzed C-N bond formation reactions to create complex amine derivatives.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Potential precursor for the synthesis of organic semiconductors or ligands for catalytic systems.
• Chemical Biology: Used in the synthesis of molecular probes and tool compounds for target identification and validation.

Basic Information

Item	Details
Product Name	tert-Butyl 6-Iodo-2,3-Dihydro-1H-Pyrido-[2,3-B][1,4]Oxazine-1-Carboxylate
CAS No.	1214932-35-0
Molecular Formula	C12H15IN2O3
Molecular Weight	362.16 g/mol
Synonyms	1,1-Dimethylethyl 6-iodo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1-carboxylate; tert-Butyl 6-iodo-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazine-1-carboxylate; 6-Iodo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1-carboxylic acid tert-butyl ester; 6-Iodo-1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine; Boc-6-iodo-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Iodo-2,3-Dihydro-1H-Pyrido-[2,3-B][1,4]Oxazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.