Description

7,7-Difluoro-5-Oxa-2-Aza-Spiro[3.4]Octane (Wx100251) is a high-value, multifunctional spirocyclic building block containing both fluorine and nitrogen-oxygen heterocycles. This compound matters for its unique three-dimensional structure and the strategic incorporation of fluorine atoms, which are critical for modulating the physicochemical and metabolic properties of advanced molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in fragment-based drug discovery and the development of protease inhibitors.

Application

• Pharmaceutical Intermediate: A key scaffold for constructing complex, three-dimensional molecular architectures in drug discovery programs, especially for central nervous system (CNS) and antiviral targets.
• Protease Inhibitor Synthesis: Used in the development of novel inhibitors for enzymes like HCV NS3/4A protease, serine proteases, and others, leveraging its spirocyclic constraint.
• Fragment-Based Drug Discovery (FBDD): Serves as a privileged, "three-dimensional" fragment library component to explore novel chemical space and improve binding affinity.
• Agrochemical Research: Employed in the synthesis of new generation herbicides and fungicides where the difluoro and spiro motifs can enhance bioactivity and environmental stability.
• Material Science Precursor: Potential monomer or cross-linking agent for developing specialty polymers with unique thermal or solubility properties.
• Synthetic Chemistry Building Block: Enables diverse chemical transformations (e.g., ring-opening, functionalization) for creating a wide array of nitrogen- and oxygen-containing heterocycles.

Basic Information

Item	Details
Product Name	7,7-Difluoro-5-Oxa-2-Aza-Spiro[3.4]Octane (Wx100251)
CAS No.	1214875-26-9
Molecular Formula	C6H7F2NO
Molecular Weight	147.12 g/mol
Synonyms	7,7-Difluoro-2-aza-5-oxaspiro[3.4]octane; 2-Aza-7,7-difluoro-5-oxaspiro[3.4]octane; 7,7-Difluoro-5-oxa-2-azaspiro[3.4]octane; WX-100251; Wx100251; AZASPIRO OCTANE DIFLUORO OXAZA; Spiro[3.4]octane, 7,7-difluoro-5-oxa-2-aza-
EINECS	Contact for details

Quality Control

Our 7,7-Difluoro-5-Oxa-2-Aza-Spiro[3.4]Octane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the original container sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.