Description

Methyl 3-Chloro-5-Fluoropyridine-2-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its precise molecular architecture, which serves as a critical intermediate in the development of complex active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used as a building block for developing next-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized pyridine derivatives for advanced materials, such as organic semiconductors and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 3-Chloro-5-Fluoropyridine-2-Carboxylate
CAS No.	1214387-31-1
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 3-chloro-5-fluoropicolinate; 3-Chloro-5-fluoropyridine-2-carboxylic acid methyl ester; 2-Pyridinecarboxylic acid, 3-chloro-5-fluoro-, methyl ester; Methyl 3-chloro-5-fluoro-2-pyridinecarboxylate; 3-Chloro-5-fluoro-2-pyridinecarboxylic acid methyl ester; Methyl 3-chloro-5-fluoropyridine-2-carboxylate; 1214387-31-1
EINECS	Contact for details

Quality Control

Our Methyl 3-Chloro-5-Fluoropyridine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.