Description

3-Bromo-4-(Difluoromethoxy)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethoxy substituents, makes it an essential intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating specialized ligands, functional polymers, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Fluorine Chemistry: The difluoromethoxy group provides a stable source of fluorine, which is valuable in medicinal chemistry for modulating lipophilicity, metabolic profile, and bioavailability.

Basic Information

Product Name	3-Bromo-4-(Difluoromethoxy)Pyridine
CAS No.	1214377-46-4
Molecular Formula	C6H4BrF2NO
Molecular Weight	224.00 g/mol
Synonyms	4-(Difluoromethoxy)-3-bromopyridine; 3-Bromo-4-difluoromethoxypyridine; Pyridine, 3-bromo-4-(difluoromethoxy)-; 1214377-46-4
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory needs in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.