Description

2-Bromo-5-Fluoro-3-Iodopyridine is a highly functionalized pyridine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), functional materials, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides due to its halogenated pyridine core.
• Material Science Precursor: Serves as a starting material for creating functionalized ligands, organic semiconductors, and liquid crystal compounds.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions, enabling the introduction of complex aryl and heteroaryl groups.
• Medicinal Chemistry Library Construction: Employed in high-throughput and parallel synthesis for generating diverse compound libraries for biological screening.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Product Name	2-Bromo-5-Fluoro-3-Iodopyridine
CAS No.	1214376-85-8
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	3-Iodo-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromo-3-iodopyridine; Pyridine, 2-bromo-5-fluoro-3-iodo-; 2-Bromo-5-fluoro-3-iodo-pyridine; 1214376-85-8; SCHEMBL21806227; BRN 15157515
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoro-3-Iodopyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.