Description

3-Chloro-2-(Difluoromethoxy)Pyridine is a high-value, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a pyridine core with chloro and difluoromethoxy substituents, enabling precise modulation of electronic and steric properties in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	3-Chloro-2-(Difluoromethoxy)Pyridine
CAS No.	1214374-09-0
Molecular Formula	C6H4ClF2NO
Molecular Weight	179.55 g/mol
Synonyms	2-(Difluoromethoxy)-3-chloropyridine; 3-Chloro-2-(difluoromethoxy)pyridine; Pyridine, 3-chloro-2-(difluoromethoxy)-; 1214374-09-0; 3-Chloro-2-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-(Difluoromethoxy)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.