Description

3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its pyridine core, carboxylic acid, and trifluoromethyl substituents. This compound matters for its unique structural features, which are critical for modulating the physicochemical and biological properties of advanced molecules in research and development. It is primarily needed by pharmaceutical, agrochemical, and advanced material scientists for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for chelating ligands in catalysis and metal-organic frameworks (MOFs) due to its carboxylic acid and hydroxyl functional groups.
• Material Science: Incorporated into polymers and advanced organic materials to impart specific electronic or surface properties.
• Chemical Biology Probe Synthesis: Utilized as a building block for creating fluorescent tags, enzyme inhibitors, and other molecular probes for biological research.

Basic Information

Product Name	3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carboxylic Acid
CAS No.	1214362-36-3
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-hydroxy-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-hydroxypicolinic acid; 3-Hydroxy-6-trifluoromethylpicolinic acid; 3-Hydroxy-6-(trifluoromethyl)picolinic acid; 3-Hydroxy-6-(trifluoromethyl)-2-pyridinecarboxylic acid; 1214362-36-3; 6-Trifluoromethyl-3-hydroxypyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications using advanced analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.