Description

Methyl 3-Chloro-5-(Trifluoromethyl)Benzoate is a high-purity, versatile benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of chloro and trifluoromethyl substituents, which are highly sought-after for modulating the physicochemical and biological properties of target molecules. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Development: Building block for polymers, coatings, and specialty chemicals requiring specific electronic or surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Custom Synthesis & R&D: Supplied to contract research organizations (CROs) and academic institutions for method development and novel compound library generation.

Basic Information

Product Name	Methyl 3-Chloro-5-(Trifluoromethyl)Benzoate
CAS No.	1214361-12-2
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)benzoic acid methyl ester; Methyl 3-chloro-α,α,α-trifluoro-m-toluate; Benzoic acid, 3-chloro-5-(trifluoromethyl)-, methyl ester; m-Chloro-α,α,α-trifluoromethylbenzoic acid methyl ester; Methyl 3-chloro-5-trifluoromethylbenzoate; Methyl 3-chloro-α,α,α-trifluoro-m-toluate; 3-Chloro-5-trifluoromethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Chloro-5-(Trifluoromethyl)Benzoate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications, including assay, identity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, and we support audits and regulatory documentation for cGMP and ISO 9001 compliant supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.