Description

Methyl 2-Amino-5-(4-Fluorophenyl)Pyridine-4-Carboxylate is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an amino and an ester functional group on a fluorinated aromatic scaffold, makes it an indispensable intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorophenyl moiety enhances bioavailability and environmental stability.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile scaffold for further derivatization, including hydrolysis to the corresponding acid, amidation, or coupling reactions to create diverse chemical libraries.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for medicinal chemistry programs and methodological studies in heterocyclic chemistry.

Basic Information

Product Name	Methyl 2-Amino-5-(4-Fluorophenyl)Pyridine-4-Carboxylate
CAS No.	1214354-57-0
Molecular Formula	C13H11FN2O2
Molecular Weight	246.24 g/mol
Synonyms	Methyl 2-amino-5-(4-fluorophenyl)isonicotinate; 4-Pyridinecarboxylic acid, 2-amino-5-(4-fluorophenyl)-, methyl ester; 2-Amino-5-(4-fluorophenyl)isonicotinic acid methyl ester; 5-(4-Fluorophenyl)-2-aminopyridine-4-carboxylic acid methyl ester; Methyl 5-(4-fluorophenyl)-2-aminopyridine-4-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Amino-5-(4-Fluorophenyl)Pyridine-4-Carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical and agrochemical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by NMR and MS), and levels of specific impurities. Our quality commitment supports your regulatory filings and ensures consistent performance in your synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.