Description

Ethyl 2-(Trifluoromethyl)Isonicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring a strategically positioned trifluoromethyl group and an ester moiety, makes it a versatile intermediate for constructing complex molecules with enhanced properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials, liquid crystals, and polymers with unique optical and electronic properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of bioactive molecules for metabolic pathway studies and target identification.

Basic Information

Product Name	Ethyl 2-(Trifluoromethyl)Isonicotinate
CAS No.	1214351-44-6
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Ethyl 2-(trifluoromethyl)pyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester; 2-(Trifluoromethyl)isonicotinic acid ethyl ester; Ethyl 2-(trifluoromethyl)isonicotinate; Isonicotinic acid, 2-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Trifluoromethyl)Isonicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.