Description

6-(Difluoromethoxy)Picolinonitrile is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy-substituted picolinonitrile structure makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine moiety for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for synthesizing functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Serves as a precursor for fluorescent tags and other molecular probes used in diagnostic and research applications.

Basic Information

Product Name	6-(Difluoromethoxy)Picolinonitrile
CAS No.	1214349-26-4
Molecular Formula	C7H4F2N2O
Molecular Weight	170.12 g/mol
Synonyms	2-Cyano-6-(difluoromethoxy)pyridine; 6-(Difluoromethoxy)-2-pyridinecarbonitrile; 2-Pyridinecarbonitrile, 6-(difluoromethoxy)-; Picolinonitrile, 6-(difluoromethoxy)-; 6-Difluoromethoxypicolinonitrile
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Picolinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.