Description

2-Bromo-6-(Difluoromethoxy)Pyridine is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethoxy substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluoromethoxy and bromopyridine motifs.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized nitrogen-containing ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where fluorine and bromine substitution modulates electronic properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-6-(Difluoromethoxy)Pyridine
CAS No.	1214345-40-0
Molecular Formula	C6H4BrF2NO
Molecular Weight	224.00 g/mol
Synonyms	6-Bromo-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-6-bromopyridine; Pyridine, 2-bromo-6-(difluoromethoxy)-; 2-Bromo-6-difluoromethoxypyridine; 1214345-40-0; 6-Bromo-2-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.