Description

3-Chloro-2-Cyano-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its unique structure, combining halogen, cyano, and trifluoromethyl substituents, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists in the agrochemical and pharmaceutical industries seeking to introduce fluorine and nitrogen-containing motifs into their target compounds.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl and pyridine moieties enhance biological activity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in creating molecules with improved metabolic stability and bioavailability.
• Material Science Research: Serves as a versatile monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The chlorine atom at the 3-position makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl systems.
• Nucleophilic Substitution: The cyano and halogen groups provide sites for further functionalization through nucleophilic aromatic substitution, enabling diverse chemical transformations.

Basic Information

Product Name	3-Chloro-2-Cyano-6-(Trifluoromethyl)Pyridine
CAS No.	1214333-69-3
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	2-Chloro-3-cyano-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-chloropyridine-2-carbonitrile; 3-Chloro-6-(trifluoromethyl)picolinonitrile; 3-Chloro-2-cyano-6-trifluoromethylpyridine; 2-Cyano-3-chloro-6-(trifluoromethyl)pyridine; Pyridine, 3-chloro-2-cyano-6-(trifluoromethyl)-; 1214333-69-3
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Cyano-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures material integrity for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.