Description

2-Bromo-6-Fluoro-Nicotinic Acid is a high-purity, multi-functional halogenated nicotinic acid derivative. This compound serves as a critical pharmaceutical intermediate and organic synthesis building block, enabling the development of novel active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides with enhanced efficacy.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions in fine chemical synthesis.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	2-Bromo-6-Fluoro-Nicotinic Acid
CAS No.	1214332-31-6
Molecular Formula	C6H3BrFNO2
Molecular Weight	219.99 g/mol
Synonyms	2-Bromo-6-fluoropyridine-3-carboxylic acid; 6-Fluoro-2-bromonicotinic acid; 3-Carboxy-2-bromo-6-fluoropyridine; 2-Bromo-6-fluoro-3-pyridinecarboxylic acid; Nicotinic acid, 2-bromo-6-fluoro-; 1214332-31-6; 2-Br-6-F-3-PyCOOH
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Fluoro-Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.