Description

Methyl 5-Bromo-3-(Trifluoromethyl)-2-Pyridinecarboxylate is a high-purity, multi-functional pyridine derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the strategic combination of bromo and trifluoromethyl substituents, which are essential for introducing key pharmacophores and modifying physicochemical properties in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of specialty chemicals and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a starting material for the synthesis of functionalized ligands, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl structures.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to optimize the potency and selectivity of drug candidates.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	Methyl 5-Bromo-3-(Trifluoromethyl)-2-Pyridinecarboxylate
CAS No.	1214328-84-3
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	5-Bromo-3-(trifluoromethyl)picolinic acid methyl ester; Methyl 5-bromo-3-(trifluoromethyl)picolinate; 2-Pyridinecarboxylic acid, 5-bromo-3-(trifluoromethyl)-, methyl ester; 5-Bromo-3-trifluoromethyl-pyridine-2-carboxylic acid methyl ester; Methyl 5-bromo-3-(trifluoromethyl)pyridine-2-carboxylate; 1214328-84-3; Methyl 5-bromo-3-(trifluoromethyl)-2-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-3-(Trifluoromethyl)-2-Pyridinecarboxylate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.