Description

Methyl 6-Bromo-5-Chloropyridine-2-Carboxylate is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its dual halogen functionality, which provides distinct reactive sites for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the bromine substituent.
• Nucleophilic Aromatic Substitution: The chlorine atom at the 5-position is activated for substitution, enabling further derivatization.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.

Basic Information

Product Name	Methyl 6-Bromo-5-Chloropyridine-2-Carboxylate
CAS No.	1214324-91-0
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	Methyl 6-bromo-5-chloropicolinate; 6-Bromo-5-chloropyridine-2-carboxylic acid methyl ester; 2-Pyridinecarboxylic acid, 6-bromo-5-chloro-, methyl ester; Methyl 5-chloro-6-bromopicolinate; 5-Chloro-6-bromo-2-pyridinecarboxylic acid methyl ester; Methyl 5-chloro-6-bromopyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-Bromo-5-Chloropyridine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal quality standards. Our commitment to cGMP principles ensures reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture uptake. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.