Description

Methyl 2-Nitro-5-Trifluoromethylbenzoate is a high-value fluorinated aromatic ester building block, essential for advanced organic synthesis. Its core value lies in the strategic combination of nitro and trifluoromethyl groups on the benzoate scaffold, enabling precise molecular modifications. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group imparts superior biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic cores for electronic and optoelectronic materials, contributing to improved performance in display technologies.
• Dye & Pigment Chemistry: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-Coupling Reactions: The nitro and ester functionalities make it a versatile substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki and Heck reactions, to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.

Basic Information

Item	Details
Product Name	Methyl 2-Nitro-5-Trifluoromethylbenzoate
CAS No.	1214324-86-3
Molecular Formula	C9H6F3NO4
Molecular Weight	249.14 g/mol
Synonyms	2-Nitro-5-(trifluoromethyl)benzoic Acid Methyl Ester; Methyl 2-Nitro-α,α,α-trifluoro-p-toluate; Benzoic acid, 2-nitro-5-(trifluoromethyl)-, methyl ester; Methyl 5-Trifluoromethyl-2-nitrobenzoate; 2-Nitro-5-trifluoromethylbenzoic Acid Methyl Ester; Methyl 2-Nitro-5-trifluoromethylbenzoate; Methyl 2-Nitro-5-(trifluoromethyl)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Nitro-5-Trifluoromethylbenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.