Description

5-Chloro-2-Fluoronicotinic Acid Methyl Ester is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals.
• Chemical Synthesis: A versatile reagent for introducing the 5-chloro-2-fluoropyridine moiety into more complex molecular architectures via cross-coupling or substitution reactions.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	5-Chloro-2-Fluoronicotinic Acid Methyl Ester
CAS No.	1214324-17-0
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 5-Chloro-2-fluoronicotinate; 5-Chloro-2-fluoro-3-pyridinecarboxylic Acid Methyl Ester; 5-Chloro-2-fluoropyridine-3-carboxylic Acid Methyl Ester; 3-Pyridinecarboxylic Acid, 5-Chloro-2-fluoro-, Methyl Ester; Methyl 5-Chloro-2-fluoro-3-pyridinecarboxylate; 1214324-17-0; 5-Chloro-2-fluoronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoronicotinic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, from research to scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.