Description

5-Chloro-2-(Difluoromethoxy)Pyridine is a high-value halogenated pyridine derivative, recognized for its unique difluoromethoxy substituent which imparts enhanced metabolic stability and lipophilicity. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors for constructing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Building block for creating next-generation herbicides and fungicides, leveraging the stability of the difluoromethoxy group.
• Material Science Research: Used in the synthesis of specialized ligands, catalysts, and functionalized polymers.
• Organic Synthesis: Versatile substrate for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the activated chlorine atom.
• Fluorine Chemistry: Valuable reagent for introducing fluorine-containing motifs into molecular architectures, a common strategy in medicinal chemistry.

Basic Information

Product Name	5-Chloro-2-(Difluoromethoxy)Pyridine
CAS No.	1214323-40-6
Molecular Formula	C6H4ClF2NO
Molecular Weight	179.55 g/mol
Synonyms	2-(Difluoromethoxy)-5-chloropyridine; 5-Chloro-2-(difluoromethoxy)pyridine; 5-Chloro-2-difluoromethoxypyridine; Pyridine, 5-chloro-2-(difluoromethoxy)-; 1214323-40-6
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 5-Chloro-2-(Difluoromethoxy)Pyridine adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.