Description

2-(Difluoromethoxy)-5-Phenylpyridine is a high-value fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its molecular structure, featuring a difluoromethoxy group attached to a phenylpyridine core, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily targeted at research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine chemistry for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical synthon for the research and development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its aromatic and fluorinated characteristics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production and scale-up projects.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Phenylpyridine
CAS No.	1214323-29-1
Molecular Formula	C12H9F2NO
Molecular Weight	221.20 g/mol
Synonyms	5-Phenyl-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-phenylpyridine; 5-Phenyl-2-(difluoromethoxy)pyridine; Pyridine, 2-(difluoromethoxy)-5-phenyl-; 1214323-29-1
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-5-Phenylpyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and commercial synthesis. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and MS analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.