Description

Glutamic Acid(Otbu)-Allyl Ester Hcl is a protected amino acid derivative widely used as a key building block in peptide synthesis and medicinal chemistry. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and process development.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial, protected glutamic acid precursor for the controlled incorporation of glutamic acid residues into peptide chains.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs), particularly for peptides and peptidomimetics.
• Linker Chemistry: The allyl ester protecting group allows for orthogonal deprotection strategies, making it valuable in complex multi-step syntheses.
• Bioconjugation: Acts as a functionalized building block for attaching peptides to other molecules, surfaces, or carriers in drug delivery systems.
• Chemical Biology Probes: Utilized in the synthesis of labeled peptides and tools for studying biological processes and protein interactions.
• Fine Chemical Synthesis: Employed as a specialized intermediate in the custom synthesis of complex organic molecules for various research applications.

Basic Information

Product Name	Glutamic Acid(Otbu)-Allyl Ester Hcl
CAS No.	1214283-78-9
Molecular Formula	C12H21NO4 • HCl
Molecular Weight	279.76 g/mol (Free base: 243.30 g/mol)
Synonyms	L-Glutamic acid 5-allyl ester 1-(1,1-dimethylethyl) ester hydrochloride; Fmoc-Glu(OAll)-OtBu hydrochloride; H-Glu(OtBu)-OAll • HCl; Allyl L-glutamate N-tert-butyl ester hydrochloride; (2S)-2-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}amino)-5-(2-propen-1-yloxy)-5-oxopentanoic acid hydrochloride; Boc-Glu(OAll)-OtBu • HCl; Glutamic acid γ-allyl ester α-tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Glutamic Acid(Otbu)-Allyl Ester Hcl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.