Description

(R)-Methyl 2-Amino-2-(5-Bromo-2-Fluorophenyl)Propanoate is a high-purity, non-natural amino acid ester derivative featuring a chiral center and halogenated aromatic ring system. This compound is a critical chiral building block for the synthesis of complex, biologically active molecules, where its specific stereochemistry is essential for efficacy. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial-scale synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead structures for targeted protein degradation therapeutics.
• Peptidomimetic Drug Design: Used to incorporate modified, non-natural amino acid motifs into peptide-based drug candidates to enhance stability and bioavailability.
• Agrochemical Research: Employed as a precursor in the development of advanced herbicides and pesticides with chiral specificity.
• Ligand and Catalyst Synthesis: Acts as a precursor for chiral ligands used in asymmetric catalysis.
• Academic and Contract Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	(R)-Methyl 2-Amino-2-(5-Bromo-2-Fluorophenyl)Propanoate
CAS No.	1213855-88-9
Molecular Formula	C₁₀H₁₁BrFNO₂
Molecular Weight	276.10 g/mol
Synonyms	Methyl (2R)-2-amino-2-(5-bromo-2-fluorophenyl)propanoate; (R)-Methyl 2-amino-2-(5-bromo-2-fluorophenyl)propionate; (R)-α-Methyl-5-bromo-2-fluoro-DL-phenylalanine methyl ester; 5-Bromo-2-fluoro-D-phenylalanine methyl ester (R-enantiomer); UNII-9F8J5F2K8R; (R)-Methyl 2-Amino-2-(5-Bromo-2-Fluorophenyl)Propanoate; Methyl (R)-2-amino-2-(5-bromo-2-fluorophenyl)propanoate; (R)-2-Amino-2-(5-bromo-2-fluorophenyl)propionic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-Amino-2-(5-Bromo-2-Fluorophenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.