Description

Methyl (2S)-2-Amino-3-(2-Fluoro-4-Methylphenyl)Propanoate CAS NO 1213632-12-2 is a high-purity, non-natural amino acid ester derivative, specifically engineered as a critical chiral building block for advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold with a fluorinated aromatic side chain, enabling the development of novel compounds with enhanced metabolic stability and binding affinity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating targeted active pharmaceutical ingredients (APIs) and sophisticated crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors, kinase inhibitors, and other targeted therapies.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the fluorine atom and specific stereochemistry are crucial for bioactivity.
• Peptidomimetics Development: Serves as a constrained amino acid analog for constructing peptide-like molecules with improved pharmacological profiles.
• Chemical Biology Probes: Incorporated into molecular probes and tags for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce complex chiral centers.
• Material Science Precursor: Potential use in synthesizing specialized monomers for advanced polymeric materials.

Basic Information

Product Name	Methyl (2S)-2-Amino-3-(2-Fluoro-4-Methylphenyl)Propanoate
CAS No.	1213632-12-2
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	(2S)-2-Amino-3-(2-fluoro-4-methylphenyl)propanoic acid methyl ester; L-2-Fluoro-4-methylphenylalanine methyl ester; Methyl L-2-amino-3-(2-fluoro-4-methylphenyl)propanoate; (S)-Methyl 2-amino-3-(2-fluoro-4-methylphenyl)propanoate; 2-Fluoro-4-methyl-DL-phenylalanine methyl ester (related); Fmoc-2-Fluoro-4-methyl-L-phenylalanine (precursor form); 1213632-12-2; 2-Fluoro-4-methyl-L-Phe-OMe
EINECS	Contact for details

Quality Control

Every batch of Methyl (2S)-2-Amino-3-(2-Fluoro-4-Methylphenyl)Propanoate is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.