Description

(S)-2-Amino-3-(2,4,6-Trimethyl-Phenyl)-Propionic Acid Methyl Ester is a high-value, non-proteinogenic amino acid derivative featuring a sterically hindered, chiral phenylalanine core. This compound is a critical chiral building block in modern organic synthesis, prized for its role in constructing complex molecules with precise stereochemistry. It is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of peptide mimetics, enzyme inhibitors, and other bioactive compounds requiring high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in peptide-based drug discovery.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic and stoichiometric asymmetric synthesis to introduce chiral centers.
• Agrochemical Research: Serves as a building block for developing advanced crop protection agents and herbicides with specific stereochemical requirements.
• Peptidomimetics: Integral for creating peptide analogs and mimetics designed for enhanced metabolic stability and receptor selectivity.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified amino acids for studying biological pathways and protein function.
• Catalyst & Ligand Development: Used in the preparation of novel chiral catalysts and ligands for enantioselective transformations.

Basic Information

Product Name	(S)-2-Amino-3-(2,4,6-Trimethyl-Phenyl)-Propionic Acid Methyl Ester
CAS No.	1213452-83-5
Molecular Formula	C13H19NO2
Molecular Weight	221.30 g/mol
Synonyms	(S)-2-Amino-3-(2,4,6-trimethylphenyl)propanoic acid methyl ester; Methyl (S)-2-amino-3-(2,4,6-trimethylphenyl)propanoate; (S)-Methyl 2-amino-3-(mesityl)propanoate; L-2-Amino-3-(2,4,6-trimethylphenyl)propionic acid methyl ester; (S)-α-Amino-2,4,6-trimethylbenzenepropanoic acid methyl ester; Methyl L-2,4,6-trimethylphenylalaninate; (S)-Methyl 2-amino-3-(2,4,6-trimethylphenyl)propionate
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(2,4,6-Trimethyl-Phenyl)-Propionic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.