Description

(S)-6-(Pyrrolidin-2-Yl)Pyridine-3-Carbonitrile is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its rigid, nitrogen-containing bicyclic structure, which is crucial for imparting specific stereochemistry and biological activity in drug molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring precise molecular recognition.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral targets.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities in drug discovery programs.
• Precursor to Biologically Active Molecules: Functionalized to create more complex molecules with potential therapeutic applications.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(S)-6-(Pyrrolidin-2-Yl)Pyridine-3-Carbonitrile
CAS No.	1213447-26-7
Molecular Formula	C10H11N3
Molecular Weight	173.22 g/mol
Synonyms	(S)-6-(2-Pyrrolidinyl)nicotinonitrile; (S)-6-(Pyrrolidin-2-yl)nicotinonitrile; (S)-2-(5-Cyanopyridin-2-yl)pyrrolidine; 3-Pyridinecarbonitrile, 6-[(2S)-2-pyrrolidinyl]-; (S)-2-(5-Cyano-2-pyridyl)pyrrolidine; (S)-6-(Pyrrolidin-2-yl)-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our (S)-6-(Pyrrolidin-2-Yl)Pyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.