Description

(R)-5-(Pyrrolidin-2-Yl)Pyridine-2-Carbonitrile is a high-purity chiral intermediate featuring a pyrrolidine-pyridine core structure. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced organic molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutics and fine chemicals. Its defined stereochemistry ensures precise biological activity in final target molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Intermediate for developing enantiopure pesticides and herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Serves as a core structure for designing molecular probes and inhibitors for biological target validation.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce complex, nitrogen-containing heterocycles.

Basic Information

Product Name	(R)-5-(Pyrrolidin-2-Yl)Pyridine-2-Carbonitrile
CAS No.	1213417-10-7
Molecular Formula	C10H11N3
Molecular Weight	173.22 g/mol
Synonyms	(R)-5-(2-Pyrrolidinyl)-2-pyridinecarbonitrile; (R)-5-(Pyrrolidin-2-yl)picolinonitrile; 2-Pyridinecarbonitrile, 5-[(2R)-2-pyrrolidinyl]-; (R)-5-(Pyrrolidin-2-yl)nicotinonitrile (common misassignment); (R)-enantiomer of 5-(Pyrrolidin-2-yl)pyridine-2-carbonitrile; (R)-Pyrrolidinyl Picolinonitrile; (R)-PPCN
EINECS	Contact for details

Quality Control

Our (R)-5-(Pyrrolidin-2-Yl)Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.