Description

Methyl (3R)-3-Amino-3-(3-Fluorophenyl)Propanoate is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug development. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and production of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of advanced drug candidates targeting neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for creating enantiomerically pure APIs.
• Asymmetric Synthesis: Serves as a versatile building block in medicinal chemistry for constructing complex molecules with defined stereochemistry.
• Biochemical Research: Employed in studies investigating structure-activity relationships (SAR) and receptor binding affinity.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.
• Reference Standard: Used as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Methyl (3R)-3-Amino-3-(3-Fluorophenyl)Propanoate
CAS No.	1213403-50-9
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	(R)-Methyl 3-amino-3-(3-fluorophenyl)propanoate; (3R)-3-Amino-3-(3-fluorophenyl)propanoic acid methyl ester; Methyl (R)-3-amino-3-(3-fluorophenyl)propionate; (R)-3-Amino-3-(3-fluorophenyl)propionic acid methyl ester; 3-Fluoro-D-β-phenylalanine methyl ester; (R)-3-(3-Fluorophenyl)-3-aminopropionic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-Amino-3-(3-Fluorophenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.