Description

Methyl (3S)-3-Amino-3-(3-Chloro-2-Fluorophenyl)Propanoate CAS NO 1213185-15-9 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapeutics. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of innovative drugs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical precursor in multi-step synthesis for final API production under GMP conditions.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and commercial manufacturing of proprietary pharmaceutical compounds.
• Bioconjugation & Prodrug Development: Used in the design of prodrugs and bioconjugates to improve drug delivery and pharmacokinetic profiles.

Basic Information

Product Name	Methyl (3S)-3-Amino-3-(3-Chloro-2-Fluorophenyl)Propanoate
CAS No.	1213185-15-9
Molecular Formula	C10H11ClFNO2
Molecular Weight	231.65 g/mol
Synonyms	(3S)-3-Amino-3-(3-chloro-2-fluorophenyl)propanoic acid methyl ester; Methyl (S)-3-amino-3-(3-chloro-2-fluorophenyl)propanoate; (S)-Methyl 3-amino-3-(3-chloro-2-fluorophenyl)propanoate; 3-Amino-3-(3-chloro-2-fluorophenyl)propanoic acid methyl ester, (3S)-; Propanoic acid, 3-amino-3-(3-chloro-2-fluorophenyl)-, methyl ester, (3S)-; 1213185-15-9; Methyl L-3-amino-3-(3-chloro-2-fluorophenyl)propionate
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-3-(3-Chloro-2-Fluorophenyl)Propanoate is manufactured under strict quality management systems. We provide material with typical purities exceeding 98.5% (HPLC) and high enantiomeric excess (>99.0% ee). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Our quality commitment aligns with ICH guidelines, and we can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.