Description

Methyl (3S)-3-Amino-3-(3,4-Difluorophenyl)Propanoate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates.
• API Development: Used in research and development for constructing the core scaffold of potential new APIs.
• Preclinical & Clinical Research: Serves as a critical material for producing compounds used in pharmacological studies and clinical trial material.
• Asymmetric Synthesis: Utilized in reactions requiring high enantioselectivity to introduce the (3S)-amino acid ester moiety.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Methyl (3S)-3-Amino-3-(3,4-Difluorophenyl)Propanoate
CAS No.	1213138-40-9
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	(3S)-3-Amino-3-(3,4-difluorophenyl)propanoic acid methyl ester; Methyl (S)-3-amino-3-(3,4-difluorophenyl)propionate; (S)-Methyl 3-amino-3-(3,4-difluorophenyl)propanoate; 3,4-Difluoro-D-β-homophenylalanine methyl ester; (S)-3-Amino-3-(3,4-difluorophenyl)propionic acid methyl ester; L-3-Amino-3-(3,4-difluorophenyl)propionic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-3-(3,4-Difluorophenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.