Description

Methyl (3S)-3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoate CAS NO 1212968-23-4 is a high-purity chiral building block of significant importance in modern pharmaceutical synthesis. This compound serves as a critical intermediate for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily utilized by research institutions, custom synthesis firms, and large-scale pharmaceutical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, especially for neurological and psychiatric applications.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients requiring a fluorinated and chlorinated phenylalanine derivative backbone.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to construct stereochemically defined complex molecules due to its (3S) configuration.
• Peptidomimetics Research: Serves as a constrained amino acid ester analog in the design and synthesis of peptide-like compounds for drug discovery.
• Agrochemical Intermediates: Potential use in the synthesis of advanced, targeted agrochemicals requiring specific halogenated aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	Methyl (3S)-3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoate
CAS No.	1212968-23-4
Molecular Formula	C10H11ClFNO2
Molecular Weight	231.65 g/mol
Synonyms	(3S)-3-Amino-3-(4-chloro-2-fluorophenyl)propanoic acid methyl ester; Methyl L-3-amino-3-(4-chloro-2-fluorophenyl)propionate; (S)-Methyl 3-amino-3-(4-chloro-2-fluorophenyl)propanoate; 4-Chloro-2-fluoro-β-alanine methyl ester (S)-enantiomer; (S)-Methyl 3-amino-3-(4-chloro-2-fluorophenyl)propionate; Methyl (S)-3-amino-3-(4-chloro-2-fluorophenyl)propanoate; 1212968-23-4; (S)-3-Amino-3-(4-chloro-2-fluorophenyl)propionic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and identification by IR, NMR, and MS. Certificates of Analysis (COA) detailing all specifications are available for every batch and provided upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.