Description

3-((2R)Pyrrolidin-2-Yl)-5-Fluoropyridine is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its unique pyrrolidine-pyridine hybrid structure, which is integral to modulating biological activity and physicochemical properties in drug discovery. It is primarily utilized by research organizations and pharmaceutical companies engaged in the development of novel therapeutics, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and high-throughput screening.
• Ligand and Probe Development: Used in the design and synthesis of receptor ligands, enzyme inhibitors, and biochemical probes for target validation.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereochemical complexity.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the scalable manufacturing of candidate drugs.

Basic Information

Product Name	3-((2R)Pyrrolidin-2-Yl)-5-Fluoropyridine
CAS No.	1212928-22-7
Molecular Formula	C9H11FN2
Molecular Weight	166.20 g/mol
Synonyms	(R)-2-(5-Fluoropyridin-3-yl)pyrrolidine; 5-Fluoro-3-[(2R)-2-pyrrolidinyl]pyridine; 3-[(2R)-Pyrrolidin-2-yl]-5-fluoropyridine; (R)-3-(5-Fluoropyridin-3-yl)pyrrolidine; (R)-5-Fluoro-3-(pyrrolidin-2-yl)pyridine; 5-Fluoro-3-((R)-pyrrolidin-2-yl)pyridine; (R)-2-(5-Fluoropyridin-3-yl)pyrrolidine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 3-((2R)Pyrrolidin-2-Yl)-5-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.