Description

n-(Piperidin-4-Yl)Nicotinamide Dihydrochloride CAS NO 1211811-66-3 is a high-purity, dihydrochloride salt derivative of a nicotinamide-piperidine hybrid compound, serving as a critical pharmaceutical intermediate and research chemical. Its molecular architecture makes it a valuable building block for medicinal chemistry, particularly in the development of novel therapeutic agents targeting the central nervous system and other disease pathways. This compound is essential for R&D laboratories, contract research organizations (CROs), and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of active pharmaceutical ingredients (APIs) for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold or building block for designing and synthesizing new chemical entities in drug discovery programs.
• Biochemical Tool Compound: Employed in in vitro studies to investigate biological pathways and receptor interactions.
• Process Development & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes from lab to pilot plant scale.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and pharmacology.

Basic Information

Item	Detail
Product Name	n-(Piperidin-4-Yl)Nicotinamide Dihydrochloride
CAS No.	1211811-66-3
Molecular Formula	C11H16N3O • 2HCl
Molecular Weight	279.19 g/mol (Free base: 206.27 g/mol)
Synonyms	4-(3-Pyridinecarboxamido)piperidine Dihydrochloride; Nicotinoyl-4-aminopiperidine Dihydrochloride; N-(Piperidin-4-yl)pyridine-3-carboxamide Dihydrochloride; 3-Pyridinecarboxamide, N-(4-piperidinyl)-, dihydrochloride; 1-(Pyridine-3-carbonyl)piperidin-4-amine Dihydrochloride; 4-Aminopiperidine-1-carbothioamide Dihydrochloride (related); Research Compound 1211811-66-3
EINECS	Contact for details

Quality Control

Our n-(Piperidin-4-Yl)Nicotinamide Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.