Description

5-Bromo-2-Methyl-4-(Trifluoromethyl)Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring bromine and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and as a probe molecule for studying protein-ligand interactions.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	5-Bromo-2-Methyl-4-(Trifluoromethyl)Pyridine
CAS No.	1211591-90-0
Molecular Formula	C8H5BrF3N
Molecular Weight	240.03 g/mol
Synonyms	4-(Trifluoromethyl)-5-bromo-2-picoline; 2-Methyl-5-bromo-4-(trifluoromethyl)pyridine; 5-Bromo-2-methyl-4-trifluoromethylpyridine; 2-Picoline, 5-bromo-4-(trifluoromethyl)-; 1211591-90-0; 5-Br-2-Me-4-CF3-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Methyl-4-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We guarantee high-purity material suitable for demanding research and scale-up applications. Comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.